| 03/10/2022 | ||
| Rayo Vallecano | 2 - 1 | Elche |
| 02/10/2022 | ||
| Real Madrid | 1 - 1 | Osasuna |
| Girona | 3 - 5 | Real Sociedad |
| Celta Vigo | 1 - 0 | Real Betis |
| Espanyol | 2 - 2 | Valencia |
| 01/10/2022 | ||
| Mallorca | 0 - 1 | Barcelona |
| Sevilla | 0 - 2 | Atlético de Madrid |
| Getafe | 2 - 3 | Real Valladolid |
| Cadiz | 0 - 0 | Villarreal |
| 30/09/2022 | ||
| Athletic Bilbao | 4 - 0 | Almeria |
| 18/09/2022 | ||
| Atlético de Madrid | 1 - 2 | Real Madrid |
| Real Sociedad | 2 - 1 | Espanyol |
| Real Betis | 2 - 1 | Girona |
| Villarreal | 1 - 1 | Sevilla |
| Osasuna | 0 - 2 | Getafe |
| 17/09/2022 | ||
| Athletic Bilbao | 3 - 2 | Rayo Vallecano |
| Valencia | 3 - 0 | Celta Vigo |
| Barcelona | 3 - 0 | Elche |
| Mallorca | 1 - 0 | Almeria |
| 16/09/2022 | ||
| Real Valladolid | 0 - 1 | Cadiz |
| # | Equipe | MJ | V | N | D | Pour | Contre | Diff. | Pts |
|---|---|---|---|---|---|---|---|---|---|
| 1 | Barcelona | 7 | 6 | 1 | 0 | 19 | 1 | +18 | 19 |
| 2 | Real Madrid | 7 | 6 | 1 | 0 | 18 | 7 | +11 | 19 |
| 3 | Athletic Bilbao | 7 | 5 | 1 | 1 | 16 | 4 | +12 | 16 |
| 4 | Real Betis | 7 | 5 | 0 | 2 | 10 | 5 | +5 | 15 |
| 5 | Atlético de Madrid | 7 | 4 | 1 | 2 | 12 | 6 | +6 | 13 |
| 6 | Osasuna | 7 | 4 | 1 | 2 | 8 | 6 | +2 | 13 |
| 7 | Real Sociedad | 7 | 4 | 1 | 2 | 12 | 11 | +1 | 13 |
| 8 | Villarreal | 7 | 3 | 3 | 1 | 10 | 2 | +8 | 12 |
| 9 | Valencia | 7 | 3 | 1 | 3 | 12 | 7 | +5 | 10 |
| 10 | Rayo Vallecano | 7 | 3 | 1 | 3 | 9 | 9 | +0 | 10 |
| 11 | Celta Vigo | 7 | 3 | 1 | 3 | 9 | 13 | -4 | 10 |
| 12 | Mallorca | 7 | 2 | 2 | 3 | 6 | 8 | -2 | 8 |
| 13 | Girona | 7 | 2 | 1 | 4 | 10 | 12 | -2 | 7 |
| 14 | Getafe | 7 | 2 | 1 | 4 | 8 | 15 | -7 | 7 |
| 15 | Real Valladolid | 7 | 2 | 1 | 4 | 6 | 13 | -7 | 7 |
| 16 | Espanyol | 7 | 1 | 2 | 4 | 9 | 14 | -5 | 5 |
| 17 | Sevilla | 7 | 1 | 2 | 4 | 7 | 13 | -6 | 5 |
| 18 | Almeria | 7 | 1 | 1 | 5 | 4 | 11 | -7 | 4 |
| 19 | Cadiz | 7 | 1 | 1 | 5 | 1 | 14 | -13 | 4 |
| 20 | Elche | 7 | 0 | 1 | 6 | 3 | 18 | -15 | 1 |
| 07/10/2022 | ||
| Osasuna | 20:00 | Valencia |
| 08/10/2022 | ||
| Almeria | 13:00 | Rayo Vallecano |
| Atlético de Madrid | 15:15 | Girona |
| Sevilla | 17:30 | Athletic Bilbao |
| Getafe | 20:00 | Real Madrid |
| 09/10/2022 | ||
| Real Valladolid | 13:00 | Real Betis |
| Cadiz | 15:15 | Espanyol |
| Real Sociedad | 17:30 | Villarreal |
| Barcelona | 20:00 | Celta Vigo |
| 10/10/2022 | ||
| Elche | 20:00 | Mallorca |
| 14/10/2022 | ||
| Rayo Vallecano | 20:00 | Getafe |
| 15/10/2022 | ||
| Girona | 13:00 | Cadiz |
| Valencia | 15:15 | Elche |
| Mallorca | 17:30 | Sevilla |
| Athletic Bilbao | 20:00 | Atlético de Madrid |
| 16/10/2022 | ||
| Celta Vigo | 13:00 | Real Sociedad |
| Real Madrid | 15:15 | Barcelona |
| Espanyol | 17:30 | Real Valladolid |
| Real Betis | 20:00 | Almeria |
| 17/10/2022 | ||
| Villarreal | 20:00 | Osasuna |
