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| 12/04/2021 |
| Celta Vigo | 3 - 4 | Sevilla |
| 11/04/2021 |
| Real Betis | 1 - 1 | Atlético de Madrid |
| Real Valladolid | 1 - 2 | Granada |
| Valencia | 2 - 2 | Real Sociedad |
| Villarreal | 1 - 2 | Osasuna |
| 10/04/2021 |
| Real Madrid | 2 - 1 | Barcelona |
| Eibar | 0 - 1 | Levante |
| Athletic Bilbao | 0 - 0 | Deportivo Alavés |
| Getafe | 0 - 1 | Cádiz |
| 09/04/2021 |
| Huesca | 3 - 1 | Elche |
| 07/04/2021 |
| Real Sociedad | 1 - 1 | Athletic Bilbao |
| 05/04/2021 |
| Barcelona | 1 - 0 | Real Valladolid |
| 04/04/2021 |
| Sevilla | 1 - 0 | Atlético de Madrid |
| Cádiz | 2 - 1 | Valencia |
| Elche | 1 - 1 | Real Betis |
| Deportivo Alavés | 1 - 3 | Celta Vigo |
| 03/04/2021 |
| Osasuna | 0 - 0 | Getafe |
| Real Madrid | 2 - 0 | Eibar |
| Granada | 0 - 3 | Villarreal |
| 02/04/2021 |
| Levante | 0 - 2 | Huesca |
| # | Equipe | MJ | V | N | D | Pour | Contre | Diff. | Pts |
|---|
| 1 | Atlético de Madrid | 30 | 20 | 7 | 3 | 52 | 20 | +32 | 67 |
| 2 | Real Madrid | 30 | 20 | 6 | 4 | 53 | 24 | +29 | 66 |
| 3 | Barcelona | 30 | 20 | 5 | 5 | 69 | 26 | +43 | 65 |
| 4 | Sevilla | 30 | 19 | 4 | 7 | 44 | 24 | +20 | 61 |
| 5 | Real Sociedad | 30 | 12 | 11 | 7 | 47 | 31 | +16 | 47 |
| 6 | Real Betis | 30 | 14 | 5 | 11 | 40 | 43 | -3 | 47 |
| 7 | Villarreal | 30 | 11 | 13 | 6 | 43 | 33 | +10 | 46 |
| 8 | Granada | 30 | 11 | 6 | 13 | 36 | 50 | -14 | 39 |
| 9 | Levante | 30 | 9 | 11 | 10 | 37 | 39 | -2 | 38 |
| 10 | Celta Vigo | 30 | 9 | 10 | 11 | 41 | 48 | -7 | 37 |
| 11 | Athletic Bilbao | 30 | 9 | 10 | 11 | 39 | 33 | +6 | 37 |
| 12 | Cádiz | 30 | 9 | 8 | 13 | 27 | 45 | -18 | 35 |
| 13 | Valencia | 30 | 8 | 10 | 12 | 37 | 42 | -5 | 34 |
| 14 | Osasuna | 30 | 8 | 10 | 12 | 25 | 36 | -11 | 34 |
| 15 | Getafe | 30 | 7 | 9 | 14 | 22 | 34 | -12 | 30 |
| 16 | Huesca | 30 | 5 | 12 | 13 | 31 | 45 | -14 | 27 |
| 17 | Real Valladolid | 30 | 5 | 12 | 13 | 27 | 41 | -14 | 27 |
| 18 | Elche | 30 | 5 | 11 | 14 | 27 | 46 | -19 | 26 |
| 19 | Deportivo Alavés | 30 | 5 | 9 | 16 | 24 | 47 | -23 | 24 |
| 20 | Eibar | 30 | 4 | 11 | 15 | 22 | 36 | -14 | 23 |
| 18/04/2021 |
| Osasuna | 13:00 | Elche |
| Real Sociedad | 13:00 | Sevilla |
| Deportivo Alavés | 15:15 | Huesca |
| Atlético de Madrid | 15:15 | Eibar |
| Real Betis | 17:30 | Valencia |
| Cádiz | 17:30 | Celta Vigo |
| Getafe | 20:00 | Real Madrid |
| Levante | 20:00 | Villarreal |
| 21/04/2021 |
| Levante | 18:00 | Sevilla |
| Osasuna | 18:00 | Valencia |
| Real Betis | 19:00 | Athletic Bilbao |
| Deportivo Alavés | 20:00 | Villarreal |
| Elche | 20:00 | Real Valladolid |
| Cádiz | 21:00 | Real Madrid |
| 22/04/2021 |
| Atlético de Madrid | 18:00 | Huesca |
| Granada | 20:00 | Eibar |
| Real Sociedad | 20:00 | Celta Vigo |
| Barcelona | 21:00 | Getafe |
